Melittin suppresses HIF-1α/VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical carcinoma cells.

Melittin suppresses HIF-1α/VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical carcinoma cells.

OBJECTIVE: Melittin (MEL), a major component of bee venom, has been associated with various diseases including arthritis, rheumatism and various cancers. In this study, the anti-angiogenic effects of MEL in CaSki cells that were responsive to the epidermal growth factor (EGF) were examined. METHODOL...

Full description

Bibliographic Details
Main Authors: Jae-Moon Shin, Yun-Jeong Jeong, Hyun-Ji Cho, Kwan-Kyu Park, Il-Kyung Chung, In-Kyu Lee, Jong-Young Kwak, Hyeun-Wook Chang, Cheorl-Ho Kim, Sung-Kwon Moon, Wun-Jae Kim, Yung-Hyun Choi, Young-Chae Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3720276?pdf=render

Internet

http://europepmc.org/articles/PMC3720276?pdf=render

Similar Items