Real-World Data on Detection of Germline and Somatic Pathogenic/Likely Pathogenic Variants in <i>BRCA1/2</i> and Other Susceptibility Genes in Ovarian Cancer Patients Using Next Generation Sequencing

Real-World Data on Detection of Germline and Somatic Pathogenic/Likely Pathogenic Variants in <i>BRCA1/2</i> and Other Susceptibility Genes in Ovarian Cancer Patients Using Next Generation Sequencing

Detection of germline and somatic pathogenic/likely pathogenic variants (PV/LPV) in BRCA genes is at the moment a prerequisite for use of PARP inhibitors in different treatment settings of different tumors. The aim of our study was to determine the most appropriate testing workflow in epithelial ova...

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Bibliographic Details
Main Authors: Vida Stegel, Ana Blatnik, Erik Škof, Vita Šetrajčič Dragoš, Mateja Krajc, Brigita Gregorič, Petra Škerl, Ksenija Strojnik, Gašper Klančar, Marta Banjac, Janez Žgajnar, Maja Ravnik, Srdjan Novaković
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
BRCA
HBOC
ovarian cancer
tumor genotyping
germline genotyping
PARP inhibitors
Online Access:https://www.mdpi.com/2072-6694/14/6/1434

Internet

https://www.mdpi.com/2072-6694/14/6/1434

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