Intramolecular interaction of NEP regulated by CRM1 ensures the unidirectional transport of M1 for the nuclear export of influenza viral ribonucleoprotein

Intramolecular interaction of NEP regulated by CRM1 ensures the unidirectional transport of M1 for the nuclear export of influenza viral ribonucleoprotein

IntroductionThe influenza virus genome consists of single-stranded RNAs and forms viral ribonucleoprotein (RNP) complexes. After viral genome replication in the nucleus, the viral RNP interacts with viral protein M1. The M1-viral RNP complex is exported to the cytoplasm via the CRM1-dependent pathwa...

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Bibliographic Details
Main Authors: Mikako Hirohama, Shun Yamashita, Masamitsu N. Asaka, Takahiro Kuroki, Atsushi Kawaguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Virology
Subjects:
CRM1
nuclear export
NEP
intramolecular interaction
influenza A virus
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2023.1232906/full

Internet

https://www.frontiersin.org/articles/10.3389/fviro.2023.1232906/full

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