Recent advances on CAR-T signaling pave the way for prolonged persistence and new modalities in clinic

Recent advances on CAR-T signaling pave the way for prolonged persistence and new modalities in clinic

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematological malignancies. The importance of the receptor costimulatory domain for long-term CAR-T cell engraftment and therapeutic efficacy was demonstrated with second-generation CAR-T cells. Fifth generation CAR...

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Bibliographic Details
Main Authors: Sergei Smirnov, Polina Mateikovich, Konstantin Samochernykh, Evgeny Shlyakhto
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
CAR (chimeric antigen receptor)
persistence
activation
costimulatory
signaling
T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335424/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335424/full

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