Farnesoid X receptor contributes to body weight-independent improvements in glycemic control after Roux-en-Y gastric bypass surgery in diet-induced obese mice

Farnesoid X receptor contributes to body weight-independent improvements in glycemic control after Roux-en-Y gastric bypass surgery in diet-induced obese mice

Objective: Roux-en-Y gastric bypass surgery (RYGB) can achieve long-term remission of type 2 diabetes. However, the specific molecular mechanism through which this occurs has remained largely elusive. Bile acid signaling through the nuclear hormone receptor farnesoid X receptor (FXR) exerts benefici...

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Bibliographic Details
Main Authors: Kun Li, Jianan Zou, Song Li, Jing Guo, Wentao Shi, Bing Wang, Xiaodong Han, Hongwei Zhang, Pin Zhang, Zengmin Miao, Yousheng Li
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Molecular Metabolism
Subjects:
Roux-en-Y gastric Bypass
Bariatric surgery
Type 2 diabetes mellitus
Glucose homeostasis
Farnesoid X receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300545

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http://www.sciencedirect.com/science/article/pii/S2212877820300545

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