CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis

CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis

ICOS/ICOSL and CD28/B7-1/B7-2 are T cell co-stimulators and CTLA-4 is an immune checkpoint inhibitor that play critical roles in the pathogenesis of neoplasia. Chitinase 3-like-1 (CHI3L1) is induced in many cancers where it portends a poor prognosis and contributes to tumor metastasis. Here we demon...

Full description

Bibliographic Details
Main Authors: Bing Ma, Suchitra Kamle, Bedia Akosman, Hina Khan, Chang-Min Lee, Chun Geun Lee, Jack A. Elias
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
chitinase 3-like-1
melanoma
metastasis
ICOS and ICOSL
CTLA-4
CD28 and B7-1 and B7-2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1056397/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1056397/full

Similar Items