Deep nasal sinus cavity microbiota dysbiosis in Parkinson’s disease
Abstract Olfactory dysfunction is a pre-motor symptom of Parkinson’s disease (PD) that appears years prior to diagnosis and can affect quality of life in PD. Changes in microbiota community in deep nasal cavity near the olfactory bulb may trigger the olfactory bulb-mediated neuroinflammatory cascade...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-12-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-021-00254-y |
| _version_ | 1827774859732582400 |
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| author | Gian Pal Vivian Ramirez Phillip A. Engen Ankur Naqib Christopher B. Forsyth Stefan J. Green Mahboobeh Mahdavinia Pete S. Batra Bobby A. Tajudeen Ali Keshavarzian |
| author_facet | Gian Pal Vivian Ramirez Phillip A. Engen Ankur Naqib Christopher B. Forsyth Stefan J. Green Mahboobeh Mahdavinia Pete S. Batra Bobby A. Tajudeen Ali Keshavarzian |
| author_sort | Gian Pal |
| collection | DOAJ |
| description | Abstract Olfactory dysfunction is a pre-motor symptom of Parkinson’s disease (PD) that appears years prior to diagnosis and can affect quality of life in PD. Changes in microbiota community in deep nasal cavity near the olfactory bulb may trigger the olfactory bulb-mediated neuroinflammatory cascade and eventual dopamine loss in PD. To determine if the deep nasal cavity microbiota of PD is significantly altered in comparison to healthy controls, we characterized the microbiota of the deep nasal cavity using 16S rRNA gene amplicon sequencing in PD subjects and compared it to that of spousal and non-spousal healthy controls. Correlations between microbial taxa and PD symptom severity were also explored. Olfactory microbial communities of PD individuals were more similar to those of their spousal controls than to non-household controls. In direct comparison of PD and spousal controls and of PD and non-spousal controls, significantly differently abundant taxa were identified, and this included increased relative abundance of putative opportunistic-pathobiont species such as Moraxella catarrhalis. M. catarrhalis was also significantly correlated with more severe motor scores in PD subjects. This proof-of-concept study provides evidence that potential pathobionts are detected in the olfactory bulb and that a subset of changes in the PD microbiota community could be a consequence of unique environmental factors associated with PD living. We hypothesize that an altered deep nasal microbiota, characterized by a putative pro-inflammatory microbial community, could trigger neuroinflammation in PD. |
| first_indexed | 2024-03-11T13:43:46Z |
| format | Article |
| id | doaj.art-e7b2df4df65c436bb918e38af5f33803 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-11T13:43:46Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-e7b2df4df65c436bb918e38af5f338032023-11-02T11:07:03ZengNature Portfolionpj Parkinson's Disease2373-80572021-12-017111010.1038/s41531-021-00254-yDeep nasal sinus cavity microbiota dysbiosis in Parkinson’s diseaseGian Pal0Vivian Ramirez1Phillip A. Engen2Ankur Naqib3Christopher B. Forsyth4Stefan J. Green5Mahboobeh Mahdavinia6Pete S. Batra7Bobby A. Tajudeen8Ali Keshavarzian9Department of Neurology, Rush University Medical CenterRush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical CenterRush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical CenterRush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical CenterRush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical CenterGenomics and Microbiome Core Facility, Rush University Medical CenterDepartment of Internal Medicine, Allergy/Immunology Division, Rush University Medical CenterDepartment of Otorhinolaryngology—Head and Neck Surgery, Rush University Medical CenterDepartment of Otorhinolaryngology—Head and Neck Surgery, Rush University Medical CenterRush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical CenterAbstract Olfactory dysfunction is a pre-motor symptom of Parkinson’s disease (PD) that appears years prior to diagnosis and can affect quality of life in PD. Changes in microbiota community in deep nasal cavity near the olfactory bulb may trigger the olfactory bulb-mediated neuroinflammatory cascade and eventual dopamine loss in PD. To determine if the deep nasal cavity microbiota of PD is significantly altered in comparison to healthy controls, we characterized the microbiota of the deep nasal cavity using 16S rRNA gene amplicon sequencing in PD subjects and compared it to that of spousal and non-spousal healthy controls. Correlations between microbial taxa and PD symptom severity were also explored. Olfactory microbial communities of PD individuals were more similar to those of their spousal controls than to non-household controls. In direct comparison of PD and spousal controls and of PD and non-spousal controls, significantly differently abundant taxa were identified, and this included increased relative abundance of putative opportunistic-pathobiont species such as Moraxella catarrhalis. M. catarrhalis was also significantly correlated with more severe motor scores in PD subjects. This proof-of-concept study provides evidence that potential pathobionts are detected in the olfactory bulb and that a subset of changes in the PD microbiota community could be a consequence of unique environmental factors associated with PD living. We hypothesize that an altered deep nasal microbiota, characterized by a putative pro-inflammatory microbial community, could trigger neuroinflammation in PD.https://doi.org/10.1038/s41531-021-00254-y |
| spellingShingle | Gian Pal Vivian Ramirez Phillip A. Engen Ankur Naqib Christopher B. Forsyth Stefan J. Green Mahboobeh Mahdavinia Pete S. Batra Bobby A. Tajudeen Ali Keshavarzian Deep nasal sinus cavity microbiota dysbiosis in Parkinson’s disease npj Parkinson's Disease |
| title | Deep nasal sinus cavity microbiota dysbiosis in Parkinson’s disease |
| title_full | Deep nasal sinus cavity microbiota dysbiosis in Parkinson’s disease |
| title_fullStr | Deep nasal sinus cavity microbiota dysbiosis in Parkinson’s disease |
| title_full_unstemmed | Deep nasal sinus cavity microbiota dysbiosis in Parkinson’s disease |
| title_short | Deep nasal sinus cavity microbiota dysbiosis in Parkinson’s disease |
| title_sort | deep nasal sinus cavity microbiota dysbiosis in parkinson s disease |
| url | https://doi.org/10.1038/s41531-021-00254-y |
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