Dithioethanol (DTE)-Conjugated Deoxyribose Cyclic Dinucleotide Prodrugs (DTE-dCDNs) as STING Agonist

Dithioethanol (DTE)-Conjugated Deoxyribose Cyclic Dinucleotide Prodrugs (DTE-dCDNs) as STING Agonist

To improve the chemical regulation on the activity of cyclic dinucleotides (CDNs), we here designed a reduction-responsive dithioethanol (DTE)-based dCDN prodrug <b>9</b> (DTE-dCDN). Prodrug <b>9</b> improved the cell permeability with the intracellular levels peaking in 2 h...

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Bibliographic Details
Main Authors: Zhiqiang Xie, Yuchen Yang, Zhenghua Wang, Dejun Ma, Zhen Xi
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
DTE-conjugated prodrug
deoxyribose cyclic dinucleotide
STING agonist
intracellular signaling
cancer immunotherapy
Online Access:https://www.mdpi.com/1422-0067/25/1/86

Internet

https://www.mdpi.com/1422-0067/25/1/86

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