SLC35A2 Deficiency Promotes an Epithelial-to-Mesenchymal Transition-like Phenotype in Madin–Darby Canine Kidney Cells

SLC35A2 Deficiency Promotes an Epithelial-to-Mesenchymal Transition-like Phenotype in Madin–Darby Canine Kidney Cells

In mammalian cells, SLC35A2 delivers UDP–galactose for galactosylation reactions that take place predominantly in the Golgi lumen. Mutations in the corresponding gene cause a subtype of a congenital disorder of glycosylation (SLC35A2-CDG). Although more and more patients are diagnosed with SLC35A2-C...

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Bibliographic Details
Main Authors: Magdalena Kot, Ewa Mazurkiewicz, Maciej Wiktor, Wojciech Wiertelak, Antonina Joanna Mazur, Andrei Rahalevich, Mariusz Olczak, Dorota Maszczak-Seneczko
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
solute carrier family 35 member A2 (SLC35A2)
Madin–Darby canine kidney (MDCK) cells
epithelial-to-mesenchymal transition (EMT)
UDP-galactose
glycosylation
Golgi complex
Online Access:https://www.mdpi.com/2073-4409/11/15/2273

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https://www.mdpi.com/2073-4409/11/15/2273

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