Modeling pulsativity in the hypothalamic–pituitary–adrenal hormonal axis
Abstract A new mathematical model for biological rhythms in the hypothalamic–pituitary–adrenal (HPA) axis is proposed. This model takes the form of a system of impulsive time-delay differential equations which include pulsatile release of adrenocorticotropin (ACTH) by the pituitary gland and a time...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-05-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-12513-w |