Modeling pulsativity in the hypothalamic–pituitary–adrenal hormonal axis

Abstract A new mathematical model for biological rhythms in the hypothalamic–pituitary–adrenal (HPA) axis is proposed. This model takes the form of a system of impulsive time-delay differential equations which include pulsatile release of adrenocorticotropin (ACTH) by the pituitary gland and a time...

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Bibliographic Details
Main Authors: Alexander N. Churilov, John G. Milton
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12513-w