A Genotyping/Phenotyping Approach with Careful Clinical Monitoring to Manage the Fluoropyrimidines-Based Therapy: Clinical Cases and Systematic Review of the Literature

A Genotyping/Phenotyping Approach with Careful Clinical Monitoring to Manage the Fluoropyrimidines-Based Therapy: Clinical Cases and Systematic Review of the Literature

Fluoropyrimidines (FP) are mainly metabolised by dihydropyrimidine dehydrogenase (DPD), encoded by the <i>DPYD</i> gene. FP pharmacogenetics, including four <i>DPYD</i> polymorphisms (<i>DPYD</i>-PGx), is recommended to tailor the FP-based chemotherapy. These poly...

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Bibliographic Details
Main Authors: Valeria Conti, Emanuela De Bellis, Valentina Manzo, Francesco Sabbatino, Francesco Iannello, Fabrizio Dal Piaz, Viviana Izzo, Bruno Charlier, Berenice Stefanelli, Martina Torsiello, Teresa Iannaccone, Albino Coglianese, Francesca Colucci, Stefano Pepe, Amelia Filippelli
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Journal of Personalized Medicine
Subjects:
DPD
DPYD polymorphisms
pharmacogenetics
fluoropyrimidines
personalised medicine
therapeutic drug monitoring
Online Access:https://www.mdpi.com/2075-4426/10/3/113

Internet

https://www.mdpi.com/2075-4426/10/3/113

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