NF-κB/p65 Competes With Peroxisome Proliferator-Activated Receptor Gamma for Transient Receptor Potential Channel 6 in Hypoxia-Induced Human Pulmonary Arterial Smooth Muscle Cells

NF-κB/p65 Competes With Peroxisome Proliferator-Activated Receptor Gamma for Transient Receptor Potential Channel 6 in Hypoxia-Induced Human Pulmonary Arterial Smooth Muscle Cells

Objective: Peroxisome proliferator-activated receptor gamma (PPARγ) has an anti-proliferation effect on pulmonary arterial smooth muscle cells (PASMCs) via the transient receptor potential channel (TRPC) and protects against pulmonary artery hypertension (PAH), whereas nuclear factor-kappa B (NF-κB)...

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Bibliographic Details
Main Authors: Yan Wang, Naijian Li, Yingfeng Wang, Guobing Zheng, Jing An, Chang Liu, Yajie Wang, Qicai Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hypoxia
pulmonary artery hypertension
transient receptor potential channel 6
store-operated calcium entry
Ca2+ influx
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.656625/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.656625/full

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