Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet

Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet

Abstract Background Transcription factors bind DNA in specific sequence contexts. In addition to distinguishing one nucleobase from another, some transcription factors can distinguish between unmodified and modified bases. Current models of transcription factor binding tend not to take DNA modificat...

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Bibliographic Details
Main Authors: Coby Viner, Charles A. Ishak, James Johnson, Nicolas J. Walker, Hui Shi, Marcela K. Sjöberg-Herrera, Shu Yi Shen, Santana M. Lardo, David J. Adams, Anne C. Ferguson-Smith, Daniel D. De Carvalho, Sarah J. Hainer, Timothy L. Bailey, Michael M. Hoffman
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-023-03070-0

Internet

https://doi.org/10.1186/s13059-023-03070-0

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