Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells

Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells

Abstract Red blood cells (RBC) are the major carriers of sphingosine-1-phosphate (S1P) in blood. Here we show that variations in RBC S1P content achieved by altering S1P synthesis and transport by genetic and pharmacological means regulate glucose uptake and metabolic flux. This is due to S1P-mediat...

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Bibliographic Details
Main Authors: Nadine Thomas, Nathalie H. Schröder, Melissa K. Nowak, Philipp Wollnitzke, Shahrooz Ghaderi, Karin von Wnuck Lipinski, Annalena Wille, Jennifer Deister-Jonas, Jens Vogt, Markus H. Gräler, Lisa Dannenberg, Tobias Buschmann, Philipp Westhoff, Amin Polzin, Malte Kelm, Petra Keul, Sarah Weske, Bodo Levkau
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44109-x

Internet

https://doi.org/10.1038/s41467-023-44109-x

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