A nonhuman primate model with Alzheimer’s disease-like pathology induced by hippocampal overexpression of human tau

A nonhuman primate model with Alzheimer’s disease-like pathology induced by hippocampal overexpression of human tau

Abstract Background Alzheimer’s disease (AD) is one of the most burdening diseases of the century with no disease-modifying treatment at this time. Nonhuman primates (NHPs) share genetic, anatomical, and physiological similarities with humans, making them ideal model animals for investigating the pa...

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Bibliographic Details
Main Authors: Zhouquan Jiang, Jing Wang, Yongpeng Qin, Shanggong Liu, Bin Luo, Fan Bai, Huiyi Wei, Shaojuan Zhang, Junjie Wei, Guoyu Ding, Long Ma, Shu He, Rongjie Chen, Ying Sun, Yi Chen, Lu Wang, Hao Xu, Xiangyu Wang, Gong Chen, Wenliang Lei
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Human tau
3R tau
4R tau
Tau hyperphosphorylation
Nonhuman primate
Online Access:https://doi.org/10.1186/s13195-024-01392-0

Internet

https://doi.org/10.1186/s13195-024-01392-0

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