A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin

A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin

BDNS and TrkB are involved in bone fracture healing by inhibiting AEP. Here the authors show that a TrkB agonist prodrug can inhibit AEP and promote bone formation in osteoporotic mice.

Bibliographic Details
Main Authors: Jing Xiong, Jianming Liao, Xia Liu, Zhaohui Zhang, Jonathan Adams, Roberto Pacifici, Keqiang Ye
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32435-5

Internet

https://doi.org/10.1038/s41467-022-32435-5

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