The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

Genotoxic agents remain the mainstay of cancer treatment. Unfortunately, the clinical benefits are often countered by a rapid tumor adaptive response. Here, we report that the oncoprotein B cell lymphoma 6 (BCL6) is a core component that confers solid tumor adaptive resistance to genotoxic stress. M...

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Bibliographic Details
Main Authors: Yanan Liu, Juanjuan Feng, Kun Yuan, Zhengzhen Wu, Longmiao Hu, Yue Lu, Kun Li, Jiawei Guo, Jing Chen, Chengbin Ma, Xiufeng Pang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
genotoxic agents
adaptive resistance
BCL6
interferon responses
combination chemotherapy
Online Access:https://elifesciences.org/articles/69255

Internet

https://elifesciences.org/articles/69255

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