A Cyclic Permutation Approach to Removing Spatial Dependency between Clustered Gene Ontology Terms

A Cyclic Permutation Approach to Removing Spatial Dependency between Clustered Gene Ontology Terms

Traditional gene set enrichment analysis falters when applied to large genomic domains, where neighboring genes often share functions. This spatial dependency creates misleading enrichments, mistaking mere physical proximity for genuine biological connections. Here we present Spatial Adjusted Gene O...

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Bibliographic Details
Main Authors: Rachel Rapoport, Avraham Greenberg, Zohar Yakhini, Itamar Simon
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biology
Subjects:
gene set enrichment analysis (GSEA)
GO annotations
spatial dependencies
cyclic permutation
replication timing
copy number alterations (CNA)
Online Access:https://www.mdpi.com/2079-7737/13/3/175

Internet

https://www.mdpi.com/2079-7737/13/3/175

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