Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown.

Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown.

Production of protein containing lengthy stretches of polyglutamine encoded by multiple repeats of the trinucleotide CAG is a hallmark of Huntington's disease (HD) and of a variety of other inherited degenerative neurological and neuromuscular disorders. Earlier work has shown that interference...

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Bibliographic Details
Main Authors: Hui-Min Cheng, Yijuang Chern, I-Hui Chen, Chia-Rung Liu, Sih-Huei Li, Seung J Chun, Frank Rigo, C Frank Bennett, Ning Deng, Yanan Feng, Chyuan-Sheng Lin, Yu-Ting Yan, Stanley N Cohen, Tzu-Hao Cheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4356588?pdf=render

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http://europepmc.org/articles/PMC4356588?pdf=render

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