Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans

Neurodegenerative diseases like Alzheimer’s disease (AD) are poised to become a global health crisis, and therefore understanding the mechanisms underlying the pathogenesis is critical for the development of therapeutic strategies. Mutations in genes encoding presenilin (PSEN) occur in mos...

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Bibliographic Details
Main Authors: Shaarika Sarasija, Kenneth R. Norman
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Antioxidants
Subjects:
Online Access:http://www.mdpi.com/2076-3921/7/9/111