Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans
Neurodegenerative diseases like Alzheimer’s disease (AD) are poised to become a global health crisis, and therefore understanding the mechanisms underlying the pathogenesis is critical for the development of therapeutic strategies. Mutations in genes encoding presenilin (PSEN) occur in mos...
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| 格式: | 文件 |
| 语言: | English |
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MDPI AG
2018-08-01
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| 丛编: | Antioxidants |
| 主题: | |
| 在线阅读: | http://www.mdpi.com/2076-3921/7/9/111 |
| _version_ | 1827834031165669376 |
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| author | Shaarika Sarasija Kenneth R. Norman |
| author_facet | Shaarika Sarasija Kenneth R. Norman |
| author_sort | Shaarika Sarasija |
| collection | DOAJ |
| description | Neurodegenerative diseases like Alzheimer’s disease (AD) are poised to become a global health crisis, and therefore understanding the mechanisms underlying the pathogenesis is critical for the development of therapeutic strategies. Mutations in genes encoding presenilin (PSEN) occur in most familial Alzheimer’s disease but the role of PSEN in AD is not fully understood. In this review, the potential modes of pathogenesis of AD are discussed, focusing on calcium homeostasis and mitochondrial function. Moreover, research using Caenorhabditis elegans to explore the effects of calcium dysregulation due to presenilin mutations on mitochondrial function, oxidative stress and neurodegeneration is explored. |
| first_indexed | 2024-03-12T05:42:59Z |
| format | Article |
| id | doaj.art-e7c4577031654fba955898e7907c1a0a |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T05:42:59Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e7c4577031654fba955898e7907c1a0a2023-09-03T05:55:38ZengMDPI AGAntioxidants2076-39212018-08-017911110.3390/antiox7090111antiox7090111Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegansShaarika Sarasija0Kenneth R. Norman1Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USADepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USANeurodegenerative diseases like Alzheimer’s disease (AD) are poised to become a global health crisis, and therefore understanding the mechanisms underlying the pathogenesis is critical for the development of therapeutic strategies. Mutations in genes encoding presenilin (PSEN) occur in most familial Alzheimer’s disease but the role of PSEN in AD is not fully understood. In this review, the potential modes of pathogenesis of AD are discussed, focusing on calcium homeostasis and mitochondrial function. Moreover, research using Caenorhabditis elegans to explore the effects of calcium dysregulation due to presenilin mutations on mitochondrial function, oxidative stress and neurodegeneration is explored.http://www.mdpi.com/2076-3921/7/9/111mitochondriacalciumC. elegansneurodegenerationalzheimer’s diseaseROSpresenilin |
| spellingShingle | Shaarika Sarasija Kenneth R. Norman Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans Antioxidants mitochondria calcium C. elegans neurodegeneration alzheimer’s disease ROS presenilin |
| title | Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans |
| title_full | Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans |
| title_fullStr | Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans |
| title_full_unstemmed | Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans |
| title_short | Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans |
| title_sort | role of presenilin in mitochondrial oxidative stress and neurodegeneration in caenorhabditis elegans |
| topic | mitochondria calcium C. elegans neurodegeneration alzheimer’s disease ROS presenilin |
| url | http://www.mdpi.com/2076-3921/7/9/111 |
| work_keys_str_mv | AT shaarikasarasija roleofpresenilininmitochondrialoxidativestressandneurodegenerationincaenorhabditiselegans AT kennethrnorman roleofpresenilininmitochondrialoxidativestressandneurodegenerationincaenorhabditiselegans |