High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression

High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression

The ubiquitin-proteasome system is a major proteolytic systemfor nonlysosomal degradation of cellular proteins. Here, we investigatedthe response of mouse embryonic stem (ES) cells underproteotoxic stress. Proteasome inhibitors induced expressionof heat shock protein 70 (HSP70) in a concentration- a...

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Bibliographic Details
Main Authors: Jeong-A Park, Young-Eun Kim, Yang-Hwa Ha, Hyung-Joo Kwon, Younghee Lee
Format: Article
Language:English
Published: Korean Society for Biochemistry and Molecular Biology 2012-05-01
Series:BMB Reports
Subjects:
Apoptosis
Embryonic stem cells
HSP70
Proteasome inhibitors
Sensitivity
Online Access:http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTVAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS01JTVEMTIwNTI0MjAyM18lMjgyOTktMzA0JTI5Qk1CXzExLTI1OS5wZGY=

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http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTVAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS01JTVEMTIwNTI0MjAyM18lMjgyOTktMzA0JTI5Qk1CXzExLTI1OS5wZGY=

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