The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence

The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence

Overproduction of reactive oxygen species (ROS) and superlative lipid peroxidation promote tumorigenesis, and mitochondrial aldehyde dehydrogenase 2 (ALDH2) is associated with the detoxification of ROS-mediated lipid peroxidation-generated reactive aldehydes such as 4-hydroxy-2-nonenal (4-HNE), malo...

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Bibliographic Details
Main Authors: Weizhen Zhu, Dechao Feng, Xu Shi, Qiang Wei, Lu Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mitochondrial acetaldehyde dehydrogenase 2
urological cancers
ferroptosis
epigenetic alterations
proteostasis
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.850145/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.850145/full

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