The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence
Overproduction of reactive oxygen species (ROS) and superlative lipid peroxidation promote tumorigenesis, and mitochondrial aldehyde dehydrogenase 2 (ALDH2) is associated with the detoxification of ROS-mediated lipid peroxidation-generated reactive aldehydes such as 4-hydroxy-2-nonenal (4-HNE), malo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.850145/full |
| _version_ | 1828374799778316288 |
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| author | Weizhen Zhu Dechao Feng Xu Shi Qiang Wei Lu Yang |
| author_facet | Weizhen Zhu Dechao Feng Xu Shi Qiang Wei Lu Yang |
| author_sort | Weizhen Zhu |
| collection | DOAJ |
| description | Overproduction of reactive oxygen species (ROS) and superlative lipid peroxidation promote tumorigenesis, and mitochondrial aldehyde dehydrogenase 2 (ALDH2) is associated with the detoxification of ROS-mediated lipid peroxidation-generated reactive aldehydes such as 4-hydroxy-2-nonenal (4-HNE), malondialdehyde, and acrolein due to tobacco smoking. ALDH2 has been demonstrated to be highly associated with the prognosis and chemoradiotherapy sensitivity of many types of cancer, including leukemia, lung cancer, head and neck cancer, esophageal cancer, hepatocellular cancer, pancreatic cancer, and ovarian cancer. In this study, we explored the possible relationship between ALDH2 and urological cancers from the aspects of ferroptosis, epigenetic alterations, proteostasis, mitochondrial dysfunction, and cellular senescence. |
| first_indexed | 2024-04-14T07:38:04Z |
| format | Article |
| id | doaj.art-e7c8f6252787466389a6dd94a646eafd |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-14T07:38:04Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e7c8f6252787466389a6dd94a646eafd2022-12-22T02:05:37ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.850145850145The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular SenescenceWeizhen ZhuDechao FengXu ShiQiang WeiLu YangOverproduction of reactive oxygen species (ROS) and superlative lipid peroxidation promote tumorigenesis, and mitochondrial aldehyde dehydrogenase 2 (ALDH2) is associated with the detoxification of ROS-mediated lipid peroxidation-generated reactive aldehydes such as 4-hydroxy-2-nonenal (4-HNE), malondialdehyde, and acrolein due to tobacco smoking. ALDH2 has been demonstrated to be highly associated with the prognosis and chemoradiotherapy sensitivity of many types of cancer, including leukemia, lung cancer, head and neck cancer, esophageal cancer, hepatocellular cancer, pancreatic cancer, and ovarian cancer. In this study, we explored the possible relationship between ALDH2 and urological cancers from the aspects of ferroptosis, epigenetic alterations, proteostasis, mitochondrial dysfunction, and cellular senescence.https://www.frontiersin.org/articles/10.3389/fcell.2022.850145/fullmitochondrial acetaldehyde dehydrogenase 2urological cancersferroptosisepigenetic alterationsproteostasismitochondrial dysfunction |
| spellingShingle | Weizhen Zhu Dechao Feng Xu Shi Qiang Wei Lu Yang The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence Frontiers in Cell and Developmental Biology mitochondrial acetaldehyde dehydrogenase 2 urological cancers ferroptosis epigenetic alterations proteostasis mitochondrial dysfunction |
| title | The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence |
| title_full | The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence |
| title_fullStr | The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence |
| title_full_unstemmed | The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence |
| title_short | The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence |
| title_sort | potential role of mitochondrial acetaldehyde dehydrogenase 2 in urological cancers from the perspective of ferroptosis and cellular senescence |
| topic | mitochondrial acetaldehyde dehydrogenase 2 urological cancers ferroptosis epigenetic alterations proteostasis mitochondrial dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.850145/full |
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