Trauma-induced heme release increases susceptibility to bacterial infection

Infection is a common complication of major trauma that causes significantly increased morbidity and mortality. The mechanisms, however, linking tissue injury to increased susceptibility to infection remain poorly understood. To study this relationship, we present a potentially novel murine model in...

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Bibliographic Details
Main Authors: Ghee Rye Lee, David Gallo, Rodrigo W. Alves de Souza, Shilpa Tiwari-Heckler, Eva Csizmadia, James D. Harbison, Sidharth Shankar, Valerie Banner-Goodspeed, Michael B. Yaffe, Maria Serena Longhi, Carl J. Hauser, Leo E. Otterbein
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-10-01
Series:JCI Insight
Subjects:
Online Access:https://doi.org/10.1172/jci.insight.150813