Gallic acid inhibits osteoclastogenesis and prevents ovariectomy-induced bone loss

Gallic acid inhibits osteoclastogenesis and prevents ovariectomy-induced bone loss

Osteoporosis is a common metabolic bone disease with a rapidly increasing prevalence, characterized by massive bone loss because of excessive osteoclast formation. Gallic acid (GA), a phenolic acid isolated from Cornus officinalis, has anti-inflammatory and anti-oxidant effects, but its effect on os...

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Bibliographic Details
Main Authors: Peng Zhang, Jiekai Ye, Jiale Dai, Ying Wang, Genjun Chen, Jinping Hu, Qimiao Hu, Jun Fei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Endocrinology
Subjects:
osteoclast
Gallic acid
Akt
ERK
JNK
osteoporosis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.963237/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.963237/full

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