Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatment

Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatment

Summary: Aberrant metabolic demand is observed in immune/inflammatory disorders, yet the role in pathogenesis remains unclear. Here, we discover that in lupus, activated B cells, including germinal center B (GCB) cells, have remarkably high glycolytic requirement for survival over T cell populations...

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Bibliographic Details
Main Authors: John J. Wilson, Jian Wei, Andrea R. Daamen, John D. Sears, Elaine Bechtel, Colleen L. Mayberry, Grace A. Stafford, Lesley Bechtold, Amrie C. Grammer, Peter E. Lipsky, Derry C. Roopenian, Chih-Hao Chang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Biological sciences
Immunology
Cell biology
Transcriptomics
Model organism
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422301564X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422301564X

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