IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis

IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis

Platelets and megakaryocytes are critical players in immune responses. Recent reports suggest infection and inflammation alter the megakaryocyte and platelet transcriptome to induce altered platelet reactivity. We determined whether nonviral sepsis induces differential platelet gene expression and r...

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Bibliographic Details
Main Authors: Robert A. Campbell, Bhanu Kanth Manne, Meenakshi Banerjee, Elizabeth A. Middleton, Abigail Ajanel, Hansjorg Schwertz, Frederik Denorme, Chris Stubben, Emilie Montenont, Samantha Saperstein, Lauren Page, Neal D. Tolley, Diana L. Lim, Samuel M. Brown, Colin K. Grissom, Douglas W. Sborov, Anandi Krishnan, Matthew T. Rondina
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-12-01
Series:The Journal of Clinical Investigation
Subjects:
Hematology
Inflammation
Online Access:https://doi.org/10.1172/JCI153014

Internet

https://doi.org/10.1172/JCI153014

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