Tromethamine improves mucociliary clearance in cystic fibrosis pigs

Tromethamine improves mucociliary clearance in cystic fibrosis pigs

Abstract In cystic fibrosis (CF), the loss of cystic fibrosis transmembrane conductance regulator (CFTR) mediated Cl− and HCO3− secretion across the epithelium acidifies the airway surface liquid (ASL). Acidic ASL alters two key host defense mechanisms: Rapid ASL bacterial killing and mucociliary tr...

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Bibliographic Details
Main Authors: Jamison J. Ash, Brieanna M. Hilkin, Nicholas D. Gansemer, Eric A. Hoffman, Joseph Zabner, David A. Stoltz, Mahmoud H. Abou Alaiwa
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Physiological Reports
Subjects:
CT imaging
cystic fibrosis
mucociliary transport
therapeutics
Online Access:https://doi.org/10.14814/phy2.15340

Internet

https://doi.org/10.14814/phy2.15340

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