NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3

NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3

<p>Abstract</p> <p>Background</p> <p>Human or animals lacking either JAK3 or the common gamma chain (γc) expression display severe combined immunodeficiency disease, indicating the crucial role of JAK3 in T-cell development and the homeostasis of the immune system. JAK3...

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Bibliographic Details
Main Authors: Kitamura Daisuke, Jayabose Somasundaram, Sandoval Claudio, Yin Chang-Hong, Jee Jun-Goo, Kim Byung-Hak, Bach Erika A, Baeg Gyeong-Hun
Format: Article
Language:English
Published: BMC 2010-02-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/36

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http://www.molecular-cancer.com/content/9/1/36

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