Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering

Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering

Summary: The application of machine learning toward DNA encoded library (DEL) technology is lacking despite obvious synergy between these two advancing technologies. Herein, a machine learning algorithm has been developed that predicts the conversion rate for the DNA-compatible reaction of a buildin...

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Bibliographic Details
Main Authors: Ke Li, Xiaohong Liu, Sixiu Liu, Yulong An, Yanfang Shen, Qingxia Sun, Xiaodong Shi, Wenji Su, Weiren Cui, Zhiqiang Duan, Letian Kuai, Hongfang Yang, Alexander L. Satz, Kaixian Chen, Hualiang Jiang, Mingyue Zheng, Xuanjia Peng, Xiaojie Lu
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Organic Chemistry
Organic Reaction
Artificial Intelligence
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303278

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220303278

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