Immune evasion in cell-based immunotherapy: unraveling challenges and novel strategies

Immune evasion in cell-based immunotherapy: unraveling challenges and novel strategies

Abstract Cell-based immunotherapies (CBIs), notably exemplified by chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy, have emerged as groundbreaking approaches for cancer therapy. Nevertheless, akin to various other therapeutic modalities, tumor cells employ counterstrategies to mani...

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Bibliographic Details
Main Authors: Yan-Ruide Li, Tyler Halladay, Lili Yang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Biomedical Science
Subjects:
Immune evasion
Cell-based immunotherapies (CBIs)
Chimeric antigen receptor (CAR)
CAR-engineered T (CAR-T) cell therapy
Tumor microenvironment (TME)
Immune checkpoint proteins
Online Access:https://doi.org/10.1186/s12929-024-00998-8

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