Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis

Abstract Myocardial ischemia reperfusion (I/R) injury is a complex process with intense inflammatory response and cardiomyocyte apoptosis. As a decoy receptor of IL-1β, Interleukin-1 receptor type 2 (IL-1R2) inhibits IL-1β signaling. However, its role in I/R injury remains unknown. Here we found tha...

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Bibliographic Details
Main Authors: Jun Lin, Qinfeng Li, Tingting Jin, Jiacheng Wang, Yingchao Gong, Qingbo Lv, Meihui Wang, Jiawen Chen, Min Shang, Yanbo Zhao, Guosheng Fu
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04533-1