The Mycotoxin Beauvericin Exhibits Immunostimulatory Effects on Dendritic Cells via Activating the TLR4 Signaling Pathway

Beauvericin (BEA), a mycotoxin of the enniatin family produced by various toxigenic fungi, has been attributed multiple biological activities such as anti-cancer, anti-inflammatory, and anti-microbial functions. However, effects of BEA on dendritic cells remain unknown so far. Here, we identified ef...

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Main Authors: Xiaoli Yang, Shafaqat Ali, Manman Zhao, Lisa Richter, Vanessa Schäfer, Julian Schliehe-Diecks, Marian Frank, Jing Qi, Pia-Katharina Larsen, Jennifer Skerra, Heba Islam, Thorsten Wachtmeister, Christina Alter, Anfei Huang, Sanil Bhatia, Karl Köhrer, Carsten Kirschning, Heike Weighardt, Ulrich Kalinke, Rainer Kalscheuer, Markus Uhrberg, Stefanie Scheu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.856230/full