Kamishoyosan and Kamikihito protect against decreased KCC2 expression induced by the P. gingivalis lipopolysaccharide treatment in PC-12 cells and improve behavioral abnormalities in male mice

Kamishoyosan and Kamikihito protect against decreased KCC2 expression induced by the P. gingivalis lipopolysaccharide treatment in PC-12 cells and improve behavioral abnormalities in male mice

Kamishoyosan (KSS) and Kamikihito (KKT) have been traditionally prescribed for neuropsychiatric symptoms in Japan. However, the molecular mechanism of its effect is not elucidated enough. On the other hand, it has been reported that lipopolysaccharide derived from Porphyromonas gingivalis (P. g LPS)...

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Bibliographic Details
Main Authors: Kazuo Tomita, Yukiko Oohara, Kento Igarashi, Junichi Kitanaka, Nobue Kitanaka, Koh-ichi Tanaka, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Mitsutaka Sugimura, Tomoaki Sato
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Heliyon
Subjects:
KCC2
LPS
GABA
Oxytocin
PC-12 cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023099929

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http://www.sciencedirect.com/science/article/pii/S2405844023099929

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