Portability of a Small-Molecule Binding Site between Disordered Proteins

Portability of a Small-Molecule Binding Site between Disordered Proteins

Intrinsically disordered proteins (IDPs) are important in both normal and disease states. Small molecules can be targeted to disordered regions, but we currently have only a limited understanding of the nature of small-molecule binding sites in IDPs. Here, we show that a minimal small-molecule bindi...

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Bibliographic Details
Main Authors: Rajesh Jaiprashad, Sachith Roch De Silva, Lisette M. Fred Lucena, Ella Meyer, Steven J. Metallo
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomolecules
Subjects:
intrinsically disordered proteins
Myc
protein-protein interaction
drug targets
SLiM
small-molecule inhibitors
Online Access:https://www.mdpi.com/2218-273X/12/12/1887

Internet

https://www.mdpi.com/2218-273X/12/12/1887

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