Defective Biomechanics and Pharmacological Rescue of Human Cardiomyocytes with Filamin C Truncations

Defective Biomechanics and Pharmacological Rescue of Human Cardiomyocytes with Filamin C Truncations

Actin-binding filamin C (FLNC) is expressed in cardiomyocytes, where it localizes to Z-discs, sarcolemma, and intercalated discs. Although FLNC truncation variants (<i>FLNCtv</i>) are an established cause of arrhythmias and heart failure, changes in biomechanical properties of cardiomyoc...

Full description

Bibliographic Details
Main Authors: Marco Lazzarino, Michele Zanetti, Suet Nee Chen, Shanshan Gao, Brisa Peña, Chi Keung Lam, Joseph C. Wu, Matthew R. G. Taylor, Luisa Mestroni, Orfeo Sbaizero
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
filamin C
atomic force microscopy
induced pluripotent stem cells
cardiomyocytes
mechanomics
arrhythmogenic cardiomyopathy
Online Access:https://www.mdpi.com/1422-0067/25/5/2942

Internet

https://www.mdpi.com/1422-0067/25/5/2942

Similar Items