CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation

CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation

Abstract Long‐term opioid use develops tolerance and attenuates analgesic effects. Upon activation, µ‐opioid receptors (MOPs) are internalized and directed to either recycling or degradation pathway. Ligand stimulation also promotes de novo MOP synthesis. These processes collaboratively regulate MOP...

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Bibliographic Details
Main Authors: Satoshi Shimizu, Atsuko Shiraki
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Pharmacology Research & Perspectives
Subjects:
CRISPR/Cas9
genome editing
internalisation
mitogen‐activated protein kinase signalling
tolerance development
μ‐opioid receptor dynamics
Online Access:https://doi.org/10.1002/prp2.933

Internet

https://doi.org/10.1002/prp2.933

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