Impaired Glucocorticoid Receptor Dimerization Aggravates LPS-Induced Circulatory and Pulmonary Dysfunction

Impaired Glucocorticoid Receptor Dimerization Aggravates LPS-Induced Circulatory and Pulmonary Dysfunction

Background: Sepsis, that can be modeled by LPS injections, as an acute systemic inflammation syndrome is the most common cause for acute lung injury (ALI). ALI induces acute respiratory failure leading to hypoxemia, which is often associated with multiple organ failure (MOF). During systemic inflamm...

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Bibliographic Details
Main Authors: Martin Wepler, Jonathan M. Preuss, Tamara Merz, Clair Hartmann, Ulrich Wachter, Oscar McCook, Josef Vogt, Sandra Kress, Michael Gröger, Marina Fink, Angelika Scheuerle, Peter Möller, Enrico Calzia, Ute Burret, Peter Radermacher, Jan P. Tuckermann, Sabine Vettorazzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
glucocorticoid receptor
lung function
endotoxic shock
inflammation
osteopontin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03152/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03152/full

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