Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

The activation of the dodecameric Ca2+/calmodulin dependent kinase II (CaMKII) holoenzyme is critical for memory formation. We now report that CaMKII has a remarkable property, which is that activation of the holoenzyme triggers the exchange of subunits between holoenzymes, including unactivated one...

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Bibliographic Details
Main Authors: Margaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves, John Kuriyan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-01-01
Series:eLife
Subjects:
CaMKII
subunit exchange
spread of activation state
single-molecule
Online Access:https://elifesciences.org/articles/01610

Internet

https://elifesciences.org/articles/01610

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