Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition.

BACKGROUND: Intact LINE-1 elements are the only retrotransposons encoded by the human genome known to be capable of autonomous replication. Numerous cases of genetic disease have been traced to gene disruptions caused by LINE-1 retrotransposition events in germ-line cells. In addition, genomic insta...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: R Brad Jones, Keith E Garrison, Jessica C Wong, Erick H Duan, Douglas F Nixon, Mario A Ostrowski
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Public Library of Science (PLoS) 2008-01-01
Cyfres:PLoS ONE
Mynediad Ar-lein:http://europepmc.org/articles/PMC2212136?pdf=render