5-Chloro-2-Guanidinobenzimidazole (ClGBI) Is a Non-Selective Inhibitor of the Human H<sub>V</sub>1 Channel

5-Chloro-2-Guanidinobenzimidazole (ClGBI) Is a Non-Selective Inhibitor of the Human H<sub>V</sub>1 Channel

5-chloro-2-guanidinobenzimidazole (ClGBI), a small-molecule guanidine derivative, is a known effective inhibitor of the voltage-gated proton (H<sup>+</sup>) channel (H<sub>V</sub>1, <i>K<sub>d</sub></i> ≈ 26 μM) and is widely used both in ion channel r...

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Bibliographic Details
Main Authors: Tibor G. Szanto, Adam Feher, Eva Korpos, Adrienn Gyöngyösi, Judit Kállai, Beáta Mészáros, Krisztian Ovari, Árpád Lányi, Gyorgy Panyi, Zoltan Varga
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceuticals
Subjects:
ClGBI
proton channel
voltage-gated ion channels
blocking kinetics
selectivity screening
Online Access:https://www.mdpi.com/1424-8247/16/5/656

Internet

https://www.mdpi.com/1424-8247/16/5/656

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