Discovery of <i>N</i>,4-Di(1<i>H</i>-pyrazol-4-yl)pyrimidin-2-amine-Derived CDK2 Inhibitors as Potential Anticancer Agents: Design, Synthesis, and Evaluation

Discovery of <i>N</i>,4-Di(1<i>H</i>-pyrazol-4-yl)pyrimidin-2-amine-Derived CDK2 Inhibitors as Potential Anticancer Agents: Design, Synthesis, and Evaluation

Cyclin-dependent kinase 2 (CDK2) has been garnering considerable interest as a target to develop new cancer treatments and to ameliorate resistance to CDK4/6 inhibitors. However, a selective CDK2 inhibitor has yet to be clinically approved. With the desire to discover novel, potent, and selective CD...

Full description

Bibliographic Details
Main Authors: Biruk Sintayehu Fanta, Jimma Lenjisa, Theodosia Teo, Lianmeng Kou, Laychiluh Mekonnen, Yuchao Yang, Sunita K. C. Basnet, Ramin Hassankhani, Matthew J. Sykes, Mingfeng Yu, Shudong Wang
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
CDK2
CDK2 inhibitor
pyrazole
<i>N</i>,4-di(1<i>H</i>-pyrazol-4-yl)pyrimidin-2-amine
antiproliferative activity
bioisosteric replacement
Online Access:https://www.mdpi.com/1420-3049/28/7/2951

Internet

https://www.mdpi.com/1420-3049/28/7/2951

Similar Items