N6-methyladenosine in 28S rRNA promotes oncogenic mRNA translation and tyrosine catabolism
Summary: Aberrant N6-methyladenosine (m6A) modification on mRNA results in dysregulated mRNA translation and cancer progression; however, the role of m6A modification on rRNA remains unclear in cancers. Here, we show that ZCCHC4 and its mediated m6A modification on 28S rRNA are upregulated in variou...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724014906 |