Compressive stress triggers fibroblasts spreading over cancer cells to generate carcinoma in situ organization

Compressive stress triggers fibroblasts spreading over cancer cells to generate carcinoma in situ organization

Abstract At the early stage of tumor progression, fibroblasts are located at the outer edges of the tumor, forming an encasing layer around it. In this work, we have developed a 3D in vitro model where fibroblasts’ layout resembles the structure seen in carcinoma in situ. We use a microfluidic encap...

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Bibliographic Details
Main Authors: Fabien Bertillot, Laetitia Andrique, Carlos Ureña Martin, Olivier Zajac, Ludmilla de Plater, Michael M. Norton, Aurélien Richard, Kevin Alessandri, Basile G. Gurchenkov, Florian Fage, Atef Asnacios, Christophe Lamaze, Moumita Das, Jean- Léon Maître, Pierre Nassoy, Danijela Matic Vignjevic
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05883-6

Internet

https://doi.org/10.1038/s42003-024-05883-6

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