<i>Dclre1c</i>-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research

<i>Dclre1c</i>-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research

Severe combined immunodeficient (SCID) mice serve as a critical model for human xenotransplantation studies, yet they often suffer from low engraftment rates and susceptibility to graft-versus-host disease (GVHD). Moreover, certain SCID strains demonstrate ‘immune leakage’, underscoring the need for...

Full description

Bibliographic Details
Main Authors: Yixiao Bin, Sanhua Wei, Ruo Chen, Haowei Zhang, Jing Ren, Peijuan Liu, Zhiqian Xin, Tianjiao Zhang, Haijiao Yang, Ke Wang, Zhuan Feng, Xiuxuan Sun, Zhinan Chen, Hai Zhang
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biomolecules
Subjects:
<i>dclre1c</i>
CRISPR/Cas9
knockout
tumor xenograft model
immune reconstitution
Online Access:https://www.mdpi.com/2218-273X/14/2/180

Internet

https://www.mdpi.com/2218-273X/14/2/180

Similar Items