Mettl14-mediated m6A modification enhances the function of Foxp3+ regulatory T cells and promotes allograft acceptance

Mettl14-mediated m6A modification enhances the function of Foxp3+ regulatory T cells and promotes allograft acceptance

N6-methyladenosine (m6A), the most prevalent form of internal mRNA modification, is extensively involved in Treg cells differentiation and function. However, the involvement of m6A in functional Treg cells for transplantation tolerance remains to be elucidated. By using an experimental transplantati...

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Bibliographic Details
Main Authors: Yanzhuo Liu, Yinglin Yuan, Zili Zhou, Yuanyuan Cui, Yan Teng, Hao Huang, Hao Yuan, Yanling Zhang, Lu Yang, Gaoping Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
N6-methyladenosine
Mettl14
Treg function
transplantation
allograft acceptance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022015/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022015/full

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