The BRD4 inhibitor JQ1 suppresses tumor growth by reducing c-Myc expression in endometrial cancer

The BRD4 inhibitor JQ1 suppresses tumor growth by reducing c-Myc expression in endometrial cancer

Abstract Background Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. Efficacy of the bromodomain 4 (BRD4) inhibitor JQ1 has been reported for the treatment of various human cancers, but its potential impact on EC remains unclear. We therefore aimed to eluci...

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Bibliographic Details
Main Authors: Yingxin Pang, Gaigai Bai, Jing Zhao, Xuan Wei, Rui Li, Jie Li, Shunxue Hu, Lu Peng, Peishu Liu, Hongluan Mao
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Translational Medicine
Subjects:
Endometrial cancer
BRD4
JQ1
Cell apoptosis
Cell cycle arrest
c-Myc
Online Access:https://doi.org/10.1186/s12967-022-03545-x

Internet

https://doi.org/10.1186/s12967-022-03545-x

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