A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

Summary: Enzyme function and evolution are influenced by the larger context of a metabolic pathway. Deleterious mutations or perturbations in one enzyme can often be compensated by mutations to others. We used comparative genomics and experiments to examine evolutionary interactions with the essenti...

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Bibliographic Details
Main Authors: Andrew F. Schober, Andrew D. Mathis, Christine Ingle, Junyoung O. Park, Li Chen, Joshua D. Rabinowitz, Ivan Junier, Olivier Rivoire, Kimberly A. Reynolds
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719306503

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http://www.sciencedirect.com/science/article/pii/S2211124719306503

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