Interleukin-6-elicited chronic neuroinflammation may decrease survival but is not sufficient to drive disease progression in a mouse model of Leigh syndrome

Interleukin-6-elicited chronic neuroinflammation may decrease survival but is not sufficient to drive disease progression in a mouse model of Leigh syndrome

Abstract Background Mitochondrial diseases (MDs) are genetic disorders characterized by dysfunctions in mitochondria. Clinical data suggest that additional factors, beyond genetics, contribute to the onset and progression of this group of diseases, but these influencing factors remain largely unknow...

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Bibliographic Details
Main Authors: Kevin Aguilar, Carla Canal, Gemma Comes, Sandra Díaz-Clavero, Maria Angeles Llanos, Albert Quintana, Elisenda Sanz, Juan Hidalgo
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Inflammation
Subjects:
Leigh syndrome
Ndufs4 KO
GFAP-IL6
Neuroinflammation
Microglia
Astrocytes
Online Access:https://doi.org/10.1186/s12950-023-00369-4

Internet

https://doi.org/10.1186/s12950-023-00369-4

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